Nurse
Donna's Wrinkle Support
Gold
Formula
(Alphalipoic Acid, DMAE, and Absorbyl
Palmitate) How do Wrinkles Form?
According to Nicolas
Perricone, M.D., who wrote The
Wrinkle Cure, a NY Times bestseller, wrinkles form due to
changes
in collagen formation and free-radical damage, because of tiny
scarring. Collagen is one protein in our skin that gives it that supple
youthfulness that we like so much. Normally, collagen molecules in the
skin slide over each other to give the skin flexibility, softness, and
resiliency. However, because collagen is an essential part of our skin,
it is susceptible to free-radical damage by external factors such as
sunlight, cigarette smoke, and air pollution, and internal body
processes, such as inflammation.
When collagen is damaged by free-radicals, its molecular composition is
changed, and a process occurs called cross-linking that prevents the
collagen molecules from "sliding" over each other. It is as if someone
installs tiny tie-bars between the molecules, and the skin then becomes
more stiff and inflexible...adding to the appearance of aging.
Benefits
- Vibrant,
Youthful
Looking Skin
- Firmer Skin
- Antioxidant
Protection
Sunlight damage is a major factor for the
development of wrinkled and aging skin. Inflammation can result due to
an enzyme that is stimulated by sunlight. Free-radical damage can
result which also activates molecules inside the cells called
transcription factors. Inflammatory processes in the body are now known
to be a major cause of accelarated aging skin. Additionally, these
transcription factors which are normally harmless can produce
collagen-digesting enzymes that can leave small defects in the skin
called "Microscarring".
Inner and Outer Beauty
The good news is that
certain antioxidants can
stimulate a similar process in the skin as previously described, but
with the opposite effect. In this process instead of the
collagen-digesting attacking all collagen, it will attack only the
damaged collagen and actually repair the tiny scars, or remove the
wrinkle that started forming. According to Dr. Perricone,
supplementation with these specific antioxidants can help the skin
become supple, youthful, and vibrant again: alphalipoic acid, DMAE, and
Ascorbyl Palmitate.
Alphalipoic Acid
Alphalipoic Acid is a
very powerful antioxidant that
plays an important role alongside Vitamin C and E. Alphalipoic acid can
even recycle Vitamins C and E after they have quenched a free-radical
in order for them to do it again. Additionally, because alphalipoic
acid is both water and fat-soluble, it can work in both the lipophilic
and hydrophilic areas of the cell making it accessible to areas where
Vitamins C and E are not able to travel.
Beyond antioxidant activity alphalipoic acid plays more important roles
in the promotion of youthful, vibrant skin. Alphalipoic acid can effect
metabolism from inside of a cell. This is important because as we get
older, our cell metabolism slows down and the cell is not able to
perform important functions as efficiently. Therefore, when alphalipoic
acid is present, the higher energy cells can perform DNA-repair more
efficiently, remove wastes, and perform metabolic functions better.
Alphalipoic acid also has a key connection in preventing the
inflammatory processes that lead to aging skin. Although the
free-radical damage that is connected to inflammation can be helped by
many types of antioxidants, most antioxidants get overwhelmed when
there is a large number of free-radicals. Alphalipoic acid, on the
other hand, can prevent the activation of certain substances in the
cell (specifically NFk-B, a type of transcription factor) that can
produce an "overdrive" of free-radical damage and inflammation.
Therefore, alphalipoic acid can actually stop the production and
assault of the large number of free-radicals associated with
inflammation.
Another area that alphalipoic acid is helpful for is in controlling the
effect of sugar imbalance on aging. Sugars can cause the cross-linking
mentioned above on our collagen molecules that lead to aging skin. When
alphalipoic acid is taken internally it can prevent this reaction for
all of our proteins and also help the uptake and balanced metabolism of
sugars by our body.
DMAE
DMAE
(dimethylaminonethanol) is described by Dr.
Perricone as an "antioxidant membrane stabilizer." DMAE can actually
incorporate itself and become part of the skin plasma membrane. Here it
works both as an antioxidant and a stablizer to the actual structure of
the membrane.
One of the components of aged-looking skin is sagging. Sagging does not
just occur because of gravity's affect on the body, but because the
tiny muscles under the skin have become loose and less responsibe to
acetylcholine; a nerve chemical that causes muscles to contract. Not
only are they less responsibe to acetylcholine, aging persons generally
produce lower qualities of acetylcholine. One way to reverse this
process is to eat more fish or supplement with other sources of DMAE,
which is a precursor to acetylcholine production.
C-Ester
(Ascorbyl Palmitate)
Vitamin C-Ester is a
special form of Vitamin C that
was designed to access the outer membrane of the cell, the part of the
cell where most of the oxidation occurs, due to its fat-soluble nature.
Vitamin C is an essential part of the collagen formation process; the
substance that gives our skin elasticity. Additionally, it is an
important antioxidant that can prevent the dangerous effects of
oxidation on the outer surface of our cell membrane and give a more
youthful appearance to skin. However, Vitamin C in its regular form is
only water soluble and cannot help to protect skin cells and membranes
very well from aging because it cannot access the areas where most of
the damage occurs.
Vitamin C-Ester is composed of L-ascorbic acid (which is regular
Vitamin C) that has been joined with a fatty acid derived from palm oil
called palmitic acid. In addition to being able to access the
fat-soluble areas of the cell to prevent free-radical damage, it has
several other benefits. When discussing bioavailability, it has 10
times the uptake into the skin compared to regular Vitamin C according
to Dr. Perricone. Suggested Use
Take 100 mg of alphalipoic acid, 100 mg of
DMAE, and
500 mg of Vitamin C-Ester daily for inner and outer beauty.
Safety
Vitamin C-Ester is a form of Vitamin C, a
known safe
vitamin for supplementation. Although there have been few studies on
the safety of alphalipoic acid in humans, doses of up to 600 mg daily
have been used by diabetics in clinical studies with no serious noted
adverse effects. The us of up to 1,600 mg of DMAE per day have been
studied with no reports of toxicity. The use of DMAE is thought to be
relatively non-toxic. Higher dosages may cause anxiety, sleeplessness
or nervousness, confusion or drowsiness.
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Nurse Donna's
So
wouldn't you think
that a 'breath mint' should contain ingredients that make this oral
environment less likely to happen? At the
very least,
there shouldn't be anything in there would make that
oral
environment WORSE, right?
But
there is a type of bad breath out there that is common to everyone that
I've been largely ignoring for the last 10 years! I refer to this type
as situational bad breath.
Situational Bad
Breath occurs in 99.9% of the world population at one time or another
(statistically just about everybody, but my lawyers make me say it like
that!). It happens when someone activates a 'trigger'
that causes the oral environment in their mouth to become more likely
for the anaerobic bacteria to begin creating the volatile sulfur
compounds (VSC's) that cause bad breath.
